Our research broadens the knowledge of kidney disease.

Read up-to-date Nephrology faculty and fellow research on Pubmed with the link below

University of Washington Nephrology Research on Pubmed

We are committed to conducting path-breaking research in order to improve the lives of people with kidney diseases. Our faculty and fellows consistently publish new research in nationally recognized journals.

A selection of recent papers:

 

Inflammation drives residual risk in chronic kidney disease: a CANTOS substudy

Ridker PM, Tuttle KR, Perkovic V, Libby P, MacFadyen JG

Hyperlipidemia and inflammation jointly contribute to atherosclerotic disease. Yet, after the initiation of statin therapy, the relative contributions of these processes may differ in patient groups, such as those with and without impaired kidney function.

The Advancing American Kidney Health Initiative: Do Not Let 80% Distract Us from the Fact that We Can Do Better

Mendu ML, Bieber SD, Watnick SG, Weiner DE.

In their manuscript, “The Advancing American Kidney Health Initiative: The Challenge of Measuring Success,” Quinn and colleagues state that the Advancing American Kidney Health (AAKH) Initiative’s goals of increasing transplantation and home dialysis to 80% for incident ESKD by 2025 “cannot be plausibly reached by increasing the utilization of home dialysis or transplantation.” Although we agree, it is imperative to highlight that the 80% target does not need to be achieved to be successful in the AAKH End Stage Renal Disease Treatment Choices (ETC) model.

A randomized controlled pilot trial of anakinra for hemodialysis inflammation

Dember LM, Hung A, Mehrotra R, Hsu JY, Raj DS, Charytan DM, Mc Causland FR, Regunathan-Shenk R, Landis JR, Kimmel PL, Kliger AS, Himmelfarb J, Ikizler TA

Chronic inflammation is highly prevalent among patients receiving maintenance hemodialysis and is associated with morbidity and mortality. Inhibiting inflammation with anti-cytokine therapy has been proposed but not well studied in this population. Therefore, we conducted the ACTION trial, a pilot, multicenter, randomized, placebo-controlled trial of an IL-1 receptor antagonist, anakinra, to evaluate safety, tolerability, and feasibility, and explore efficacy.

Does More Serum Creatinine Really Just Mean Less Volume?

Kula AJ, Bansal N

Studies in critically ill adults found that correcting serum creatinine to account for potential dilution secondary to volume overload improved recognition of AKI and association with adverse outcomes. Similarly, studies of pediatric AKI have repeatedly found that volume-adjusting serum creatinine before applying creatinine-based AKI definitions resulted in a stronger association between AKI and mortality. However, the human body is not a simple static and closed system, suggesting the need for a methodologic examination of the relationship between creatinine concentration and volume-related effects.

Considerations in Controlling for Urine Concentration for Biomarkers of Kidney Disease Progression After Acute Kidney Injury

Wen Y, Thiessen-Philbrook H, Moledina DG, Kaufman JS, Reeves WB, Ghahramani N, Ikizler TA, Go AS, Liu KD, Siew ED, Himmelfarb J, Kimmel PL, Hsu CY, Parikh CR.

Introduction: Biomarkers of acute kidney injury (AKI) are often indexed to urine creatinine (UCr) or urine osmolarity (UOsm) to control for urine concentration. We evaluated how these approaches affect the biomarker-outcome association in patients with AKI. Methods: The Assessment, Serial Evaluation and Subsequent Sequelae in Acute Kidney Injury Study was a cohort of hospitalized patients with and without AKI between 2009 and 2015. Using Cox proportional hazards regression, we assessed the associations and predictions (C-statistics) of urine biomarkers with a composite outcome of incident chronic kidney disease (CKD) and CKD progression. We used 4 approaches to account for urine concentration: indexing and adjusting for UCr and UOsm.

Automated Office Blood Pressure and the Impact of Attendance and Rest on Diagnostic Accuracy

Green BB, Anderson ML, Cook AJ, Ehrlich K, Hall YN, Margolis KL, Thompson MJ

Automated office blood pressure (AOBP) using 3–5 measurements taken with an oscillometric device with or without an attendant in the room may decrease the “white coat” effect. We evaluated the impact of the presence or absence of the attendant and rest on BP and diagnosis of hypertension.

On the importance of the interplay of residual renal function with clinical outcomes in end-stage kidney disease

Tanriover C, Ucku D, Basile C, Tuttle KR, Kanbay M

Chronic kidney disease (CKD) is one of the most important public health concerns of the century, and is associated with high rates of morbidity, mortality and social costs. CKD evolving towards end-stage kidney disease (ESKD) is on the rise resulting in a greater number of patients requiring peritoneal dialysis (PD) and hemodialysis (HD). The aim of this manuscript is to review the current literature on the interplay of residual renal function (RRF) with clinical outcomes in ESKD.

Association of Intra-individual Differences in Estimated GFR by Creatinine Versus Cystatin C With Incident Heart Failure

Debbie C. Chen, MD, Michael G. Shlipak, MD, MPH, Rebecca Scherzer, PhD, Nisha Bansal, MD, MAS, O Alison Potok, MD, Dena E. Rifkin, MD, MS, Joachim H. Ix, MD, MAS, Anthony N. Muiru, MD, MPH, Chi-yuan Hsu, MD, MSc, Michelle M. Estrella, MD, MHS 
 

Rationale & Objective: Lower estimated glomerular filtration rate (eGFR) is associated with heart failure (HF) risk. However, eGFR based on cystatin C (eGFRcys) and creatinine (eGFRcr) may differ substantially within an individual. The clinical implications of these differences for risk of HF among persons with chronic kidney disease (CKD) are unknown.

Differences Among Racial and Ethnic Minority Groups in the Unmet Existential and Supportive Care Needs of People Receiving Dialysis

Catherine R Butler, Rashmi K Sharma, Nwamaka D Eneanya, Gwen M Bernacki, Jasleen K Ghuman, J Randall Curtis, Ann M O'Hare

Racial and ethnic minority groups experience a disproportionate burden of kidney disease in the US and are less likely than White individuals to receive recommended kidney care. Advanced kidney disease and treatments, such as dialysis and transplant, can be life-changing, physically demanding, and psychosocially challenging, and many patients report unmet existential and supportive care needs. To our knowledge, whether these types of care needs differ between racial and ethnic minority groups is not known.

Proteomics and Population Biology in the Cardiovascular Health Study (CHS): design of a study with mentored access and active data sharing

Thomas R Austin, Caitlin P McHugh, Jennifer A Brody, Joshua C Bis, Colleen M Sitlani, Traci M Bartz, Mary L Biggs, Nisha Bansal, Petra Buzkova, et al.

Background: In the last decade, genomic studies have identified and replicated thousands of genetic associations with measures of health and disease and contributed to the understanding of the etiology of a variety of health conditions. Proteins are key biomarkers in clinical medicine and often drug-therapy targets. Like genomics, proteomics can advance our understanding of biology.