Our faculty research broadens the knowledge of kidney disease.

Heroin Use Is Associated with AA-Type Kidney Amyloidosis in the Pacific Northwest

Arjun Sharma, Priyanka Govindan, Mirna Toukatly, Jack Healy, Connor Henry, Steve Senter, Behzad Najafian, Bryan Kestenbaum

AA-type kidney amyloidosis is classically associated with chronic autoimmune or inflammatory disorders. However, some urban centers have reported a high prevalence of injection drug use among patients with kidney AA amyloidosis. Previous reports lack control groups to quantify associations and most predate the opioid epidemic in the United States.

Hospice Use And End-Of-Life Spending Trajectories In Medicare Beneficiaries On Hemodialysis

Ann M. O’Hare, Susan M. Hailpern, Melissa Wachterman, William Kreuter, Ronit Katz, Yoshio N. Hall, Maria Montez-Rath, Manjula Kurella Tamura, Kenn B. Daratha

Infrequent and late referral to hospice among patients on dialysis likely reflects the impact of a Medicare payment policy that discourages the concurrent receipt of these services, but it may also reflect these patients’ less predictable illness trajectories. Among a national cohort of patients on hemodialysis, we identified four distinct spending trajectories during the last year of life that represented markedly different intensities of care.

Willingness to Consider Increased-Risk Donors: A Single-Center Experience in Kidney Transplantation

Vanessa L. Richards, Christopher K. Johnson, James D. Perkins, Ajit P. Limaye, Lena Sibulesky

The number of Public Health Service increased-risk organ donors (PHS IRD) is growing, largely from an increase in intravenous drug use overdoses due to the current opioid epidemic.

Goal-Striving Stress Is Associated with Chronic Kidney Disease Among Participants in the Jackson Heart Study

Cain LR, Glover L, Young B, Sims M
 

Research that assesses the relationship between psychosocial factors and chronic kidney disease (CKD) among African Americans (AAs) is limited. Using the Jackson Heart Study (JHS) cohort data, we investigated the association of goal-striving stress (GSS)-the stress experienced from not reaching goals-with prevalent CKD among AAs.

Dietary Potential Renal Acid Load and Risk of Albuminuria and Reduced Kidney Function in the Jackson Heart Study

Banerjee T, Tucker K, Griswold M, Wyatt SB, Harman J, Young B, Taylor H, Powe NR

Diets high in sulfur-rich protein and low in fruit and vegetables affect human acid-base balance adversely and may have a harmful effect on progression of chronic kidney disease (CKD). Little is known about the relationship of participant characteristics, dietary acid load (DAL), and kidney injury in African-Americans with high risk of CKD progression.

Serum Uromodulin: A Biomarker of Long-Term Kidney Allograft Failure

Bostom A, Steubl D, Garimella PS, Franceschini N, Roberts MB, Pasch A, Ix JH, Tuttle KR, Ivanova A, Shireman T, Kim SJ, Gohh R, Weiner DE, Levey AS, Hsu CY, Kusek JW, Eaton CB.

Uromodulin is a kidney-derived glycoprotein and putative tubular function index. Lower serum uromodulin was recently associated with increased risk for kidney allograft failure in a preliminary, longitudinal single-center -European study involving 91 kidney transplant recipients (KTRs).

Race in America: What Does It Mean for Diabetes and CKD?

Disparities in healthcare access and quality; social determinants of health.

Numbers or symptoms: when to initiate dialysis?

There are two competing principles that feed into the decision on the timing of initiation of long-term dialysis for patients with end-stage kidney disease. On the one hand is the premise that maintenance dialysis has the potential to improve the quality and quantity of life of most patients with end-stage kidney disease. On the other hand, long-term dialysis imposes a significant burden of treatment as patients have to make substantial and sustained changes to their lives to accommodate the dialysis schedule.

Unintended Consequences in Use of Increased Risk Donor Kidneys in the New Kidney Allocation Era

Rahnemai-Azar AA, Perkins JD, Leca N, Blosser CD, Johnson CK, Morrison SD, Bakthavatsalam R, Limaye AP, Sibulesky L.

The new kidney allocation system (KAS) intends to allocate the top 20% of kidneys to younger recipients with longer life expectancy. We hypothesized that the new KAS would lead to greater allocation of Public Health Service (PHS) increased-risk donor organs to younger recipients.

Characteristics and Outcomes of Patients with Anti-Glomerular Basement Membrane Antibody Disease and Anti-Neutrophil Cytoplasmic Antibodies

Balderia P, Andeen N, Jefferson JA

It is unclear whether patients with anti-glomerular basement membrane (GBM) disease and anti-neutrophil cytoplasmic antibodies (ANCA), so called “double-positive” (DP), have a different clinical presentation and outcome compared to patients with anti-GBM antibody disease alone. This study describes the clinical and histologic characteristics as well as the patient and renal outcomes of DP patients at the University of Washington compared to patients with anti-GBM antibody disease alone.