Our research broadens the knowledge of kidney disease.

Read up-to-date Nephrology faculty research on Pubmed with the link below

University of Washington Nephrology Faculty Research on Pubmed

We are committed to conducting path-breaking research in order to improve the lives of people with kidney diseases. Our faculty consistently publish new research in nationally recognized journals.


A selection of recent papers:

 

International Variation in Time on Peritoneal Dialysis: Time for a Closer Look?

Globally, a vexing problem in the care of individuals with kidney failure is how best to allocate limited health care resources to provide dialysis treatment to the greatest number of patients while maximizing survival and optimizing other patient-important outcomes, such as health-related quality of life and access to kidney transplantation.

Framingham and American College of Cardiology/American Heart Association Pooled Cohort Equations, High-Sensitivity Troponin T, and N-Terminal Pro-Brain-Type Natriuretic Peptide for Predicting Atherosclerotic Cardiovascular Events Across the Spectrum of Ki

Lidgard B, Zelnick LR, Go A, O'Brien KD, Bansal N; CRIC Study Investigators 

Background: Contemporary guidelines recommend using atherosclerotic cardiovascular disease screening tools to guide primary prevention. The performance of these scores is not well known in patients with moderate to advanced chronic kidney disease, particularly in combination with clinically available cardiac biomarkers including N‐terminal pro–brain‐type natriuretic peptide and high‐sensitivity troponin T (hsTnT).

The Role of Dialysis Organizations in Promoting and Facilitating Access to Nondialytic Treatment Options

No abstract available

Genetic Variants Associated with Mineral Metabolism Traits in Chronic Kidney Disease

Laster ML, Rowan B, Chen HC, Schwantes-An TH, Sheng X, Friedman PA, Ikizler TA, Sinshiemer JS, Ix JH, Susztak K, de Boer IH, Kestenbaum B, Hung A, Moe SM, Perwad F, Robinson-Cohen C

Background and objectives: Chronic kidney disease (CKD) causes multiple interrelated disturbances in mineral metabolism. Genetic studies in the general population have identified common genetic variants associated with circulating phosphate, calcium, parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23). In this study we aimed to discover genetic variants associated with circulating mineral markers in Chronic Kidney Disease.

Mentoring women well: Perspectives of junior physician-scientists on what it really takes

Jennerich AL, Brown CE, Khandelwal N, Sharma RK, Wong SPY

The life of a physician-scientist is fast paced, at many times exhausting and simultaneously exhilarating. Never-ending demands, both from our work and personal lives, make it challenging to take the time necessary to reflect on where we are, how we arrived here, and where we are ultimately headed. Then, in a flash, something earth-shattering happens to us or someone we care about. In those moments, when life makes the least sense, we are forced to pause. The news of a terminal diagnosis for our beloved mentor, Randy Curtis, was one such moment. Now, we stop and consider the ways he has contributed to our personal growth and professional careers and continues to support us in all our endeavors.

Leading from the Heart

Boss RD, Creutzfeldt CJ, Fausto JA, Gonzales MJ, Grudzen CR, Hurd CJ, Kamal AH, Lam DY, Lindvall C, Merlin JS, Reinke LF, Roeland EJ, Rosenberg AR, Sanders JJ, Smith CB, Sullivan DR, Tjia J, Walling AM.

The Sojourns Scholar Leadership Program was founded in 2014 by the Cambia Health Foundation to enable emerging palliative care leaders to execute impactful projects and grow as national leaders in the field. Since the program's inception, J. Randall “Randy” Curtis, MD, MPH has been deeply involved in this vital endeavor: serving on the advisory board and personally mentoring eighteen scholars. Randy has sharpened our thoughts, guided our growth, and imparted wisdom in the process.

Association of rheumatoid arthritis with mortality in chronic kidney disease: a cohort study

Mary N. Ezeanuna, David K. Prince, Swetha Ann Alexander, John S. Richards, Gail S. Kerr, Diana Jalal, Nisha Bansal, Jean W. Liew & Namrata Singh 

Background: Rheumatoid arthritis (RA) is associated with an increased risk of cardiovascular disease (CVD) as well as with an increased risk of chronic kidney disease (CKD), also a known cardiovascular risk factor. However, it is not known if RA is a predictor of adverse outcomes in patients with CKD. We hypothesized that among a cohort of patients with CKD, RA would be associated with an increased risk of mortality.

Supporting scholarship in palliative care across the medical specialties

In this essay, we share our experiences as three academic nephrologists at different stages in our careers who work closely with Randy Curtis at the University of Washington. Our experiences provide a window on Randy's remarkable ability to support scholarship in palliative care outside his own specialty of pulmonary and critical care medicine. We begin by providing a brief description of our experiences working with Randy and what this has meant to each of us. We then draw on these individual and collective experiences to distill out key practices that we think are especially conducive to supporting scholarship outside one's own area of specialization.

Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation

Rajasree Menon, Andrew S. Bomback, Blue B. Lake, Christy Stutzke, Stephanie M. Grewenow, Steven Menez, Vivette D. D’Agati, Sanjay Jainfor, the Kidney Precision Medicine Project
 

The Kidney Precision Medicine Project (KPMP) and the Human Biomolecular Atlas Project (HuBMAP) have generated a comprehensive molecular atlas of the kidney from more than 400,000 cells that define healthy and injured cell types and states in AKI and chronic kidney disease. Using the atlas as a resource to perform deep interrogation of a biopsy from a patient participant with AKI, we applied single-cell analysis and detailed morphologic and pathway analysis to gain molecular insights into cellular diversity, injury states, and outcome.

Implications of Cross-System Use Among US Veterans With Advanced Kidney Disease in the Era of the MISSION Act: A Qualitative Study of Health Care Records

O'Hare AM, Butler CR, Laundry RJ, Showalter W, Todd-Stenberg J, Green P, Hebert PL, Wang V, Taylor JS, Van Eijk M, Matthews KL, Crowley ST, Carey E.

A Qualitative Study of Health Care Records: Question: What themes pertaining to cross-system use emerge from the review of the Veterans Affairs (VA) health system records of patients with advanced kidney disease?Findings: In this qualitative study of electronic health records of 1000 US veterans with advanced kidney disease, 3 dominant themes pertaining to VA-financed care outside the VA were identified. Themes described the VA as the mothership, the hidden work of veterans, and strain on the VA system. Meaning Findings of this qualitative analysis highlights the substantial strain on the VA system, VA staff and clinicians, and veterans and their families of cross-system use.