Our faculty research broadens the knowledge of kidney disease.

Differential Expression of Parietal Epithelial Cell and Podocyte Extracellular Matrix Proteins in Focal Segmental Glomerulosclerosis and Diabetic Nephropathy

Gek Cher Chan, Diana G. Eng, Jeffrey H. Miner, Charles E. Alpers, Kelly L Hudkins, Anthony Chang, Jeffrey W. Pippin, Stuart J Shankland

This study aimed to define individual ECM protein isoform expression by PECs in both experimental and human focal segmental glomerulosclerosis (FSGS) and diabetic nephropathy (DN), and to determine if changes were CD44-dependent.

CD9 Is a Novel Target in Glomerular Diseases Typified by Parietal Epithelial Cell Activation

Smeets, B., Miesen, L., Shankland, S.J.

During the past decades, the pathogenic role of parietal epithelial cells (PECs) in focal segmental glomerulosclerosis (FSGS) and crescentic glomerulonephritis (GN) has become evident. The development of the extracapillary lesions in FSGS and crescentic GN is closely associated with PEC activation. PEC activation describes the phenotypic switch from their normal quiescent state to one in which they proliferate and migrate to the glomerular tuft, leading to glomerular injury.

Brenner and Rector's The Kidney, 2-Volume Set, 11th Edition

Chapter 85 "Stem Cells, Kidney Regeneration, Gene and Cell Therapy in Nephrology"

Cardiac Biomarkers and Risk of Incident Heart Failure in Chronic Kidney Disease

Bansal N, Zelnick L, Go A, Anderson A, Christenson R, Deo R, Defilippi C, Lash J, He J, Ky B, Seliger S, Soliman E, Shlipak M; CRIC Study Investigators 

Cardiac biomarkers may signal mechanistic pathways involved in heart failure (HF), a leading complication in chronic kidney disease. We tested the associations of NT‐proBNP (N‐terminal pro‐B‐type natriuretic peptide), high‐sensitivity troponin T (hsTnT), galectin‐3, growth differentiation factor‐15 (GDF‐15), and soluble ST2 (sST2) with incident HF in chronic kidney disease. We examined adults with chronic kidney disease enrolled in a prospective, multicenter study. All biomarkers were measured at baseline.

Serum Calcification Propensity and Clinical Events in CKD

Joshua D. BundyXuan CaiRupal C. MehtaJulia J. SciallaIan H. de BoerChi-yuan HsuAlan S. GoMirela A. DobreJing ChenPanduranga S. RaoMary B. LeonardJames P. LashGeoffrey A. BlockRaymond R. TownsendHarold I. FeldmanEdward R. SmithAndreas PaschTamara Isakova and the CRIC Study Investigators

Patients with CKD are at high risk for cardiovascular disease, ESKD, and mortality. Vascular calcification is one pathway through which cardiovascular disease risks are increased. We hypothesized that a novel measure of serum calcification propensity is associated with cardiovascular disease events, ESKD, and all-cause mortality among patients with CKD stages 2–4.

Longitudinal Evolution of Markers of Mineral Metabolism in Patients With CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study

Tamara Isakova, Xuan Cai, Jungwha Lee, Rupal Mehta, Xiaoming Zhang, Wei Yang, Lisa Nessel, Amanda Hyre Anderson, Joan Lo, Anna Porter, Julie Wright Nunes, Lavinia Negrea, Lee Hamm, Edward Horwitz, Jing Chen, Julia J. Scialla, Ian H. de Boer, Mary B. Leonard, Harold I. Feldman, Myles Wolf, on behalf of the CRIC Study Investigators

The pathogenesis of disordered mineral metabolism in chronic kidney disease (CKD) is largely informed by cross-sectional studies of humans and longitudinal animal studies. We sought to characterize the longitudinal evolution of disordered mineral metabolism during the course of CKD.

Ethical Concerns in the Care of Patients with Advanced Kidney Disease: a National Retrospective Study, 2000–2011

Catherine R. Butler, Elizabeth K. Vig, Ann M. O’Hare, Chuan-Fen Liu, Paul L. Hebert. Susan P.Y. Wong

Understanding ethical concerns that arise in the care of patients with advanced kidney disease may help identify opportunities to support medical decision-making. The objective is to describe the clinical contexts and types of ethical concerns that arise in the care of patients with advanced kidney disease.

Tissue Chips in Space—Challenges and Opportunities

Catherine K. Yeung,  Paul Koenig,  Stefanie Countryman,  Kenneth E. Thummel,  Jonathan Himmelfarb,  Edward J. Kelly

The microgravity environment results in a multitude of physiological changes associated with aging and altered organ function. Deployment of microphysiological systems, also known as “tissue chips” to the International Space Station United States National Laboratory, will allow the study of these changes at the cellular/molecular level. The goal of these studies is to expand understanding of age‐related conditions to improve human health on earth.

Vitamin D Metabolic Ratio and Risks of Death and CKD Progression

Bansal, N., Katz, R., Appel, L., Denburg, M., Feldman, H., Go, A.S., He, J., Hoofnagle, A., Isakova, T., Kestenbaum, B., Kusek, J., Lash, J., Leonard, M., Rahman, M., Robinson-Cohen, C., Wolf, M., Xie, D., Zelnick, L., de Boer, I.H., Appel, L., Feldman, H., Kusek, J.W., Lash, J.P., Rao, P.S., Townsend, R.R., CRIC Study Investigators

Assessment of impaired vitamin D metabolism is limited by lack of functional measures. CYP24A1-mediated vitamin D clearance, calculated as the ratio of serum 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 (the vitamin D metabolic ratio, VDMR), is induced by 1,25-dihydroxyvitamin D and may assess tissue-level activity. We tested associations of the VDMR with risks of death and progression to end-stage renal disease (ESRD) in patients with chronic kidney disease (CKD).

Differential Expression of Parietal Epithelial Cell and Podocyte Extracellular Matrix Proteins in Focal Segmental Glomerulosclerosis and Diabetic Nephropathy

Gek Cher Chan, Diana G. Eng, Jeffrey H. Miner, Charles E. Alpers, Kelly L Hudkins, Anthony Chang, Jeffrey W. Pippin, Stuart J Shankland

This study aimed to define individual ECM protein isoform expression by PECs in both experimental and human focal segmental glomerulosclerosis (FSGS) and diabetic nephropathy (DN), and to determine if changes were CD44-dependent.