Our faculty research broadens the knowledge of kidney disease.

Association of Soluble TNFR-1 Concentrations with Long-Term Decline in Kidney Function: The Multi-Ethnic Study of Atherosclerosis

Pavan K. Bhatraju, Leila R. Zelnick, Michael Shlipak, Ronit KatzBryan Kestenbaum

TNF receptor-1 (TNFR-1), which plays a causative role in endothelial cell dysfunction and inflammation, is expressed on the cell surface in glomerular and peritubular capillary endothelium of the kidneys. Higher soluble TNF receptor-1 (sTNFR-1) concentrations are associated with kidney disease progression among persons with established diabetic kidney disease. However, no studies have assessed sTNFR-1’s role in long-term kidney function changes in a multiethnic population without cardiovascular disease at baseline.

Vitamin D and OmegA-3 TriaL to prevent and treat diabetic kidney disease: Rationale, design, and baseline characteristics

de Boer IH, Zelnick LR, Lin J, Schaumberg D, Wang L, Ruzinski J, Friedenberg G, Duszlak J, Bubes VY, Hoofnagle AN, Thadhani R, Glynn RJ, Buring JE, Sesso H, Manson JE.

Diabetic kidney disease (DKD), defined as reduced glomerular filtration rate (GFR), elevated urine albumin excretion, or both that is clinically attributable to diabetes, is a common and morbid diabetes complication. Animal-experimental data, observational human studies, and short-term clinical trials suggest that vitamin D and omega-3 fatty acid supplements may be safe and inexpensive interventions to reduce the incidence and progression of DKD.

Strategies to Improve Patient Engagement in Young Kidney Transplant Recipients: A Review.

Richards VL, Johnson CK, Blosser CD, Sibulesky L.

Young adult and adolescent kidney transplant recipients have shorter graft survival than older and younger recipients. Although multifactorial, the tendency toward premature graft loss in young kidney transplant recipients has often been attributed to medication nonadherence and the transition from pediatric to adult care.

Genetic Variants Associated with Circulating Fibroblast Growth Factor 23

Cassianne Robinson-Cohen, Traci M. Bartz, Dongbing Lai, T. Alp Ikizler, Munro Peacock, Erik A. Imel, Erin D. Michos, Tatiana M. Foroud, Kristina Akesson, Kent D. Taylor, Linnea Malmgren, Kunihiro Matsushita, Maria Nethander, Joel Eriksson, Claes Ohlsson, Daniel Mellström, Myles Wolf, Osten Ljunggren, Fiona McGuigan, Jerome I. Rotter, Magnus Karlsson, Michael J. Econs, Joachim H. Ix, Pamela L. Lutsey, Bruce M. Psaty, Ian H. de Boer, Bryan R. Kestenbaum

Fibroblast growth factor 23 (FGF23), a bone-derived hormone that regulates phosphorus and vitamin D metabolism, contributes to the pathogenesis of mineral and bone disorders in CKD and is an emerging cardiovascular risk factor. Central elements of FGF23 regulation remain incompletely understood; genetic variation may help explain interindividual differences.

Chronic kidney disease attenuates the plasma metabolome response to insulin

Roshanravan B, Zelnick LR, Djucovic D, Gu H, Alvarez JA, Ziegler TR, Gamboa JL, Utzschneider K, Kestenbaum B, Himmelfarb J, Kahn SE, Raftery D, de Boer IH

Chronic kidney disease (CKD) leads to decreased sensitivity to the metabolic effects of insulin, contributing to protein energy wasting and muscle atrophy. Targeted metabolomics profiling during hyperinsulinemic-euglycemic insulin clamp testing may help identify aberrant metabolic pathways contributing to insulin resistance in CKD.

Young Kidney Professionals' Perspectives and Attitudes about Consuming Scientific Information: A Focus Group Study

Tong A, Crews DC, Schell JO, de Boer IH, Chonchol M, Mehrotra R

The digital era has seen rapid changes in how information is consumed. Traditional dissemination of scholarly work through biomedical journals may not be optimally tailored to the preferences of younger clinicians and researchers. We aimed to describe the perspectives of young clinicians and researchers in kidney disease on consuming scientific information. Three focus groups were conducted during the 2017 American Society of Nephrology Kidney Week with a total of 29 nephrologists and researchers (ages 40 years old and younger) purposively sampled through our networks and the American Society of Nephrology registration database. Data were analyzed thematically.

Complications of Immunosuppression in Glomerular Disease

This review describes the side effects of immunosuppressive agents used in recent randomized, controlled trials of glomerular disease, and highlights some of the key adverse events that determine the choice and prescription of these medications.

Mapping Progress in Reducing Cardiovascular Risk with Kidney Disease: A Focus on Heart Failure

Although the population of patients with kidney disease and concurrent HF continues to grow, knowledge of HF therapies specifically in the CKD and ESKD population remains limited. This article will review known and emerging therapies for HF among patients with CKD and patients with ESKD, briefly summarize the implications of known and novel therapies on current clinical practice, and outline possible areas for further investigation.

Cells of NG2 lineage increase in glomeruli of mice following podocyte depletion

Suzuki T, Eng DG, McClelland AD, Pippin JW, Shankland SJ

Under certain circumstances, podocytes can be partially replaced following their loss in disease. The inability of podocytes to proliferate suggests that replacement derives from other cell types.

Telehealth and Home Dialysis: A New Option for Patients in the United States

Bieber SD, Weiner DE

Telehealth and Home Dialysis