Our faculty research broadens the knowledge of kidney disease.
Willingness to Consider Increased-Risk Donors: A Single-Center Experience in Kidney Transplantation
The number of Public Health Service increased-risk organ donors (PHS IRD) is growing, largely from an increase in intravenous drug use overdoses due to the current opioid epidemic.
Goal-Striving Stress Is Associated with Chronic Kidney Disease Among Participants in the Jackson Heart Study
Research that assesses the relationship between psychosocial factors and chronic kidney disease (CKD) among African Americans (AAs) is limited. Using the Jackson Heart Study (JHS) cohort data, we investigated the association of goal-striving stress (GSS)-the stress experienced from not reaching goals-with prevalent CKD among AAs.
Dietary Potential Renal Acid Load and Risk of Albuminuria and Reduced Kidney Function in the Jackson Heart Study
Diets high in sulfur-rich protein and low in fruit and vegetables affect human acid-base balance adversely and may have a harmful effect on progression of chronic kidney disease (CKD). Little is known about the relationship of participant characteristics, dietary acid load (DAL), and kidney injury in African-Americans with high risk of CKD progression.
Serum Uromodulin: A Biomarker of Long-Term Kidney Allograft Failure
Uromodulin is a kidney-derived glycoprotein and putative tubular function index. Lower serum uromodulin was recently associated with increased risk for kidney allograft failure in a preliminary, longitudinal single-center -European study involving 91 kidney transplant recipients (KTRs).
Race in America: What Does It Mean for Diabetes and CKD?
Disparities in healthcare access and quality; social determinants of health.
Numbers or symptoms: when to initiate dialysis?
There are two competing principles that feed into the decision on the timing of initiation of long-term dialysis for patients with end-stage kidney disease. On the one hand is the premise that maintenance dialysis has the potential to improve the quality and quantity of life of most patients with end-stage kidney disease. On the other hand, long-term dialysis imposes a significant burden of treatment as patients have to make substantial and sustained changes to their lives to accommodate the dialysis schedule.
Unintended Consequences in Use of Increased Risk Donor Kidneys in the New Kidney Allocation Era
The new kidney allocation system (KAS) intends to allocate the top 20% of kidneys to younger recipients with longer life expectancy. We hypothesized that the new KAS would lead to greater allocation of Public Health Service (PHS) increased-risk donor organs to younger recipients.
Characteristics and Outcomes of Patients with Anti-Glomerular Basement Membrane Antibody Disease and Anti-Neutrophil Cytoplasmic Antibodies
It is unclear whether patients with anti-glomerular basement membrane (GBM) disease and anti-neutrophil cytoplasmic antibodies (ANCA), so called “double-positive” (DP), have a different clinical presentation and outcome compared to patients with anti-GBM antibody disease alone. This study describes the clinical and histologic characteristics as well as the patient and renal outcomes of DP patients at the University of Washington compared to patients with anti-GBM antibody disease alone.
Reevaluating the Evidence for Blood Pressure Targets in Type 2 Diabetes
There is general consensus that treating adults with type 2 diabetes mellitus (T2DM) and hypertension to a target blood pressure (BP) of <140/90 mmHg helps prevent cardiovascular disease (CVD). Whether more intensive BP control should be routinely targeted remains a matter of debate.
Evolution of Echocardiographic Measures of Cardiac Disease From CKD to ESRD and Risk of All-Cause Mortality: Findings From the CRIC Study
Abnormal cardiac structure and function are common in chronic kidney disease (CKD) and end-stage renal disease (ESRD) and linked with mortality and heart failure. We examined changes in echocardiographic measures during the transition from CKD to ESRD and their associations with post-ESRD mortality.