Our research broadens the knowledge of kidney disease.

Read up-to-date Nephrology faculty research on Pubmed with the link below

University of Washington Nephrology Faculty Research on Pubmed

We are committed to conducting path-breaking research in order to improve the lives of people with kidney diseases. Our faculty consistently publish new research in nationally recognized journals.


A selection of recent papers:

 

Establishing a core outcome measure for life participation in patients receiving peritoneal dialysis: A Standardised Outcomes in Nephrology–Peritoneal Dialysis consensus workshop report

Cheetham MS, Wilkie M, Loud F, Manera KE, Ju A, Figueiredo A, Farragher J, Hurst H, Jassal SV, Mehrotra R, Morton RL, Schwartz D, Shen JI, Walker R, Cho Y, Johnson DW, Craig JC, Anumudu S, Baumgart A, Gonzalez AM, Scholes-Robertson N, Viecelli AK, Tong A; SONG-PD Life Participation Workshop Investigators.

Background: Life participation is an outcome of critical importance to patients receiving peritoneal dialysis (PD). However, there is no widely accepted or validated tool for measuring life participation in patients receiving PD. Methods: Online consensus workshop to identify the essential characteristics of life participation as a core outcome, with the goal of establishing a patient-reported outcome measure for use in all trials in patients receiving PD. Thematic analysis of transcripts was performed.

Using human-centered design principles to create a decision aid on conservative kidney management for advanced kidney disease

Susan P. Y. Wong, Taryn Oestreich, Bridgett Chandler, J. Randall Curtis

Background: Most patients are unaware of approaches to treating advanced chronic kidney disease (CKD) other than dialysis. Methods: We developed a dedicated decision aid on conservative kidney management using human-centered design principles in 3 phases: 1) Discovery: engagement of informants to understand their needs; 2) Design: multiple rapid cycles of ideation, prototyping, and testing of a decision aid with a small group of informants; and 3) Implementation: testing the decision aid in real-world settings with attention to how the decision aid can be further refined.

Prevalence of SGLT2i and GLP1RA use among US adults with type 2 diabetes

Limonte CP, Hall YN, Trikudanathan S, Tuttle KR, Hirsch IB, de Boer IH, Zelnick LR

Aims: To determine national prevalence of sodium-glucose contransporter-2 inhibitor (SGLT2i) and glucagon-like peptide-1 receptor agonist (GLP1RA) use among adults with type 2 diabetes mellitus (T2DM). Methods: We studied adults with T2DM and eGFR ≥ 30 mL/min/1.73 m2 who participated in the cross-sectional National Health and Nutrition Examination Survey (NHANES), focusing on the 2017-2020 examination cycle, a key time period prior to widespread dissemination of pivotal trial results and corresponding clinical practice guidelines.

Learnings from Throwing Paint at the Wall for COVID-19 with an SGLT2 Inhibitor

What really was the biologic rationale for giving hydroxychloroquine or ivermectin for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection? Conversely, why were so many people opposed to vaccines made by scientifically sound methodology? Although these are, admittedly, rhetoric questions, they represent common prevailing thoughts that permeated cultures and societies worldwide. In sum, the COVID-19 pandemic has been a story of a public health emergency with desperate attempts to try (e.g., hydroxychloroquine, ivermectin) or, contrarily, avoid (e.g., vaccines) almost anything if a story could be concocted for it.

Kidney microphysiological models for nephrotoxicity assessment

Mahadeo A, Yeung CK, Himmelfarb J, Kelly EJ

Nephrotoxicity testing is an important step in preclinical development of new molecular entities (NMEs) and has traditionally been performed in 2-D cell culture systems and animal models. However, 2-D culture systems fail to replicate complex in vivo microenvironment and animal models face interspecies differences including the overexpression of drug transporters. In the last decade, 3-D microphysiological systems (MPS) have been developed to address these concerns. Here, we review recent advancements in kidney MPS and their application in drug-induced toxicity testing and kidney disease research.

Safety of Empagliflozin in Patients With Type 2 Diabetes and Chronic Kidney Disease: Pooled Analysis of Placebo-Controlled Clinical Trials

Tuttle KR, Levin A, Nangaku M, Kadowaki T, Agarwal R, Hauske SJ, Elsäßer A, Ritter I, Steubl D, Wanner C, Wheeler DC.

OBJECTIVE: To assess the safety of empagliflozin in patients with type 2 diabetes and moderate to severe chronic kidney disease (CKD) (category G3–4) enrolled in clinical trials.

Kidney Disease, Hypertension Treatment, and Cerebral Perfusion and Structure

Kurella Tamura M, Gaussoin S, Pajewski NM, Zaharchuk G, Freedman BI, Rapp SR, Auchus AP, Haley WE, Oparil S, Kendrick J, Roumie CL, Beddhu S, Cheung AK, Williamson JD, Detre JA, Dolui S, Bryan RN, Nasrallah IM; SPRINT Research Group (includes Watnick S).

The safety of intensive blood pressure (BP) targets is controversial for persons with chronic kidney disease (CKD). We studied the effects of hypertension treatment on cerebral perfusion and structure in individuals with and without CKD.

Association of Proximal Tubular Secretory Clearance with Long-Term Decline in Cognitive Function

Lidgard B, Bansal N, Zelnick L, Hoofnagle A, Chen J, Colaizzo D, Dobre M, Mills K, Porter A, Rosas S, Sarnak M, Seliger S, Sondheimer J, Kurella Tamura M, Yaffe K, Kestenbaum B

Background: Persons with chronic kidney disease (CKD) are at high risk for cognitive impairment and progressive cognitive decline. Retention of protein-bound organic solutes that are normally removed by tubular secretion is hypothesized to contribute to cognitive impairment in CKD. Methods: We followed 2362 participants who were initially free of cognitive impairment and stroke in the prospective Chronic Renal Insufficiency Cohort (CRIC) Study. We estimated tubular secretory clearance by the 24-hour kidney clearances of eight endogenous solutes that are primarily eliminated by tubular secretion. CRIC study investigators assessed participants' cognitive function annually...

Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia

Nelly M. Cruz, Raghava Reddy, José L. McFaline-Figueroa, Christine Tran, Hongxia Fu & Benjamin S. Freedman

The functions of cilia—antenna-like organelles associated with a spectrum of disease states—are poorly understood, particularly in human cells. Here we show that human pluripotent stem cells (hPSCs) edited via CRISPR to knock out the kinesin-2 subunits KIF3A or KIF3B can be used to model ciliopathy phenotypes and to reveal ciliary functions at the tissue scale.

The VA Life-Sustaining Treatment Decisions Initiative: A qualitative analysis of veterans with advanced kidney disease

Wong SPY, Foglia MB, Cohen J, Oestreich T, O'Hare AM

Documentation of patients' goals of care is integral to promoting goal-concordant care. In 2017, the Department of Veterans Affairs (VA) launched a system-wide initiative to standardize documentation of patients' preferences for life-sustaining treatments (LST) and related goals-of-care conversations (GoCC) that included using a note template in its national electronic medical record system. We describe implementation of the LST note based on documentation in the medical records of patients with advanced kidney disease, a group that has traditionally experienced highly intensive patterns of care.