Our faculty research broadens the knowledge of kidney disease.

Characterization of Glomerular Sox9+ Cells in Anti-Glomerular Basement Membrane Nephritis in the Rat

Prochnicki A, Amann K, Wegner M, Sock E, Pfister E, Shankland S, Pippin J, Daniel C

Mechanisms of glomerular crescent formation and podocyte repair processes are still unclear. Therefore, we investigated the expression of the transcription factor Sox9 as a potential marker of a subpopulation of parietal epithelial cells (PECs) with potential regenerative properties. Glomerular Sox9 expression was characterized in detail in a rat anti-glomerular basement membrane (GBM) nephritis model using immunofluorescence and confocal laser scanning microscopy.

Reconstructing the Human Renal Vascular-Tubular Unit In Vitro

Rayner SG, Phong KT, Xue J, Lih D, Shankland SJ, Kelly EJ, Himmelfarb J, Zheng Y

Engineered human kidney-on-a-chip platforms show tremendous promise for disease modeling and drug screening. Outstanding challenges exist, however, in reconstructing the complex architecture, cellular make-up, and matrix composition necessary for the proper modeling of kidney function. Herein, the first fully tunable human kidney-on-a-chip platform is reported that allows the reconstruction of the native architecture of the renal endothelial-epithelial exchange interface using entirely cell-remodelable matrix and patient-derived kidney cells.

Cardiovascular Events after New-Onset Atrial Fibrillation in Adults with CKD: Results from the Chronic Renal Insufficiency Cohort (CRIC) Study

Nisha Bansal, Dawei Xie, Daohang Sha, Lawrence J. Appel, Rajat Deo, Harold I. Feldman, Jiang He, Kenneth Jamerson, John W. Kusek, Steven Messe, Sankar D. Navaneethan, Mahboob Rahman, Ana Catherine Ricardo, Elsayed Z. Soliman, Raymond Townsend and Alan S. Go

Atrial fibrillation (AF), the most common sustained arrhythmia in CKD, is associated with poor clinical outcomes in both patients without CKD and patients with dialysis-treated ESRD. However, less is known about AF-associated outcomes in patients with CKD who do not require dialysis.

Association of Medicaid Expansion With 1-Year Mortality Among Patients With End-Stage Renal Disease

Shailender Swaminathan, Benjamin D. Sommers, Rebecca Thorsness, Rajnish Mehrotra, Yoojin Lee, Amal N. Trivedi

In this observational study of 236,246 nonelderly patients with end-stage renal disease initiating dialysis comparing mortality between the preexpansion period and the postexpansion period, the change in 1-year mortality among patients in Medicaid expansion states compared with those in nonexpansion states was −0.8% vs −0.2%, a difference that was statistically significant. Among patients with end-stage renal disease initiating dialysis, the ACA Medicaid expansion was associated with significant improvements in 1-year survival.

Advanced dialysis fellowship

Munshi R, Winrow RM, Wu JS, Treit K, Bieber SD

End‐stage renal disease (ESRD) requiring dialysis or transplantation once thought to be an orphan disease now affects over 400,000 patients in the United States.Currently, renal transplantation offers the best option for renal replacement therapy. However, majority of patients with ESRD are treated by dialysis. Significant advancements have been made in dialysis technology since chronic dialysis became a viable option in 1960.

Recurrent Polyuria

Arora N, Durvasula R

To recognize fellowship programs’ educational mission, AJKD is using its popular Quiz feature to highlight Nephrology Fellowship programs when an author is a Nephrology Fellow. To participate, Fellowship Program Directors mentor fellows in submitting prospective Quizzes; those that are selected for publication include a brief description of the fellowship program from the Director. For “Recurrent Polyuria,” the first author is Nayan Arora, a Nephrology Fellow at the University of Washington.

Prevalence of Hypertension and Cardiovascular Risk According to Blood Pressure Thresholds Used for Diagnosis

Lamprea-Montealegre JA, Zelnick LR, Hall YN, Bansal N, de Boer IH

We sought to estimate the prevalence of hypertension and characteristics of hypertensive adults in the United States according to blood pressure (BP) thresholds used for diagnosis and estimate their associated cardiovascular disease risk.

Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip

Sakolish C, Weber EJ, Kelly EJ, Himmelfarb J, Mouneimne R, Grimm FA, House JS, Wade T, Han A, Chiu WA, Rusyn I

Tissue chips are promising new technology, they have the potential to serve as a valuable tool in biomedical research, as well as pharmaceutical development with regards to testing for efficacy and safety. The principal goals of this study were to validate a previously established proximal tubule tissue chip model in an independent laboratory and to extend its utility to testing of nephrotoxic compounds.

Can we mitigate the effects of simultaneous liver-kidney transplantation through increased utilization of HCV-positive donors?

Sibulesky L, Perkins JD, Landis CS, Johnson CK.

The MELD era has seen a significant rise in the numbers of simultaneous liver‐kidney transplantations (SLK). Prior to August 2017 there had not been any specific national policy addressing the allocation of the deceased‐donor kidneys to patients with liver failure who were on dialysis or with renal failure. A new SLK policy was recently implemented, establishing standardized national guidelines for the allocation of kidneys to SLK recipients

Simultaneous liver and kidney transplantation: How to expand the kidney donor pool?

Walter K, Johnson CK, Sibulesky L

Simultaneous dual-kidney liver transplantation (DLKT) in the United States. The first thing that strikes us is the very rarity of the procedure.