Our research broadens the knowledge of kidney disease.

Read up-to-date Nephrology faculty research on Pubmed with the link below

University of Washington Nephrology Faculty Research on Pubmed

We are committed to conducting path-breaking research in order to improve the lives of people with kidney diseases. Our faculty consistently publish new research in nationally recognized journals.


A selection of recent papers:

 

Should Oral Anticoagulation Be Used in ESKD Patients on Hemodialysis with Atrial Fibrillation?: CON

Atrial fibrillation (AF) is common in patients with ESKD and is associated with a high rate of mortality and stroke. In the general population, clinical trial data have demonstrated that anticoagulation is effective in decreasing rates of stroke without markedly increasing rates of bleeding. However, existing data on the benefits and risks of anticoagulation for the prevention of AF-related complications in the ESKD population are conflicting; thus, the evidence does not support their use in patients on hemodialysis.

Physiology Assays in Human Kidney Organoids

Kidney organoids derived from human pluripotent stem cells constitute a novel model of disease, development, and regenerative therapy. Organoids are human, experimentally accessible, high throughput, and enable reconstitution of tissue-scale biology in a petri dish. While gene expression patterns in organoid cells have been analyzed extensively, less is known about the functionality of these structures. Here we review assays of physiological function in human kidney organoids, best practices for quality control, and future applications.

Premature Death in Kidney Transplant Recipients: The Time for Trials is Now

Vinson AJ, Singh S, Chadban S, Cherney D, Gaber O, Gill JS, Helgeson E, Herzog CA, Jardine M, Jha V, Kasiske BL, Mannon RB, Michos ED, Mottl AK, Newby K, Roy-Chaudhury P, Sawinski D, Sharif A, Sridhar VS, Tuttle KR, Vock DM, Matas A

Kidney transplantation improves survival and quality of life and reduces health care costs compared with maintenance dialysis. With the development of better immunosuppressive drugs, antivirals, and patient care protocols, short-term outcomes have improved. However, kidney transplant (KT) recipients remain at increased risk for mortality and achieve only 70%–75% of the life expectancy of age-matched individuals in the general population

Pulmonary Surfactant Protein B Carried by HDL Predicts Incident Cardiovascular Disease in Patients with Type 1 Diabetes

Shao B, Snell-Bergeon JK, Pyle LL, Thomas KE, de Boer IH, Kothari V, Segrest J, Davidson WS, Bornfeldt KE, Heinecke JW.

Atherosclerotic cardiovascular disease (CVD) is the major cause of death in patients with type 1 diabetes mellitus (T1DM). Alterations in the HDL proteome have been shown to associate with prevalent CVD in T1DM. We therefore sought to determine which proteins carried by HDL might predict incident CVD in T1DM patients. Using targeted MS/MS, we quantified 50 proteins in HDL from 181 T1DM subjects enrolled in the prospective Coronary Artery Calcification in Type 1 Diabetes study (CACTI). We used Cox proportional regression analysis and a case-cohort design to test associations of HDL proteins with incident CVD (myocardial infarction, coronary artery bypass grafting, angioplasty, or death from coronary heart disease). We found that only one HDL protein—SFTPB (pulmonary surfactant protein B)—predicted incident CVD in all of the models tested.

Participant Characteristics and Attendance Patterns for a Multispecialty Veterans Affairs ECHO Program 2012-2018

Mattox EA, Yantsides KE, Borgerding J, Beste LA, Parsons EC, Fleet M, Palen BN, O'Hearn D, Germani MW, Chang MF

Introduction: The Veteran Integrated Service Network (VISN) 20 Veterans Affairs-Extension for Community Healthcare Outcomes (VA-ECHO) program connects specialty and primary care providers (PCPs) across large geographic areas, utilizing video-teleconferencing with the intention of increasing access to care among underserved and isolated populations. No previously published work describes participation patterns of a multispecialty ECHO program. We describe the development of the VISN 20 VA-ECHO program to inform the design and evaluation of ECHO programs. Methods: The participant cohort included VA-affiliated licensed health care professionals, including trainees, who attended at least one VISN 20 VA-ECHO session between April 2012 and December 2018. Participant characteristics reported include gender, clinical location, clinical specialty, discipline, and rurality.

Hypertension with Kidney Failure

A 62-year-old woman with a history of kidney failure secondary to polycystic kidney disease treated with hemodialysis (HD) presents for her regular dialysis treatment. She currently dialyzes via a left upper extremity....

Kidney repair and regeneration: perspectives of the NIDDK Re(Building) a Kidney consortium

Bilal A. Naved, Joseph V. Bonventre, Jeffrey A. Hubbell, Neil A. Hukriede, Benjamin D. Humphreys, Carl Kesselman, M. Todd Valerius, Andrew P. McMahon, Stuart J. Shankland, Jason A. Wertheim, Michael J.V. White, Mark P. de Caestecker, Iain A. Drummond
 

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Patient-Reported Symptoms and Subsequent Risk of Myocardial Infarction in Chronic Kidney Disease

Lidgard B, Zelnick LR, O'Brien KD, Bansal N

To determine whether typical atherosclerotic symptoms are associated with risk for subsequent myocardial infarction in people with CKD, we examined participants from the Chronic Renal Insufficiency Cohort Study. Chest pain, shortness of breath, and inability to climb stairs were evaluated annually using the Kidney Disease Quality of Life Instrument.

US Renal Data System 2021 Annual Data Report: Epidemiology of Kidney Disease in the United States

Johansen KL, Chertow GM, Gilbertson DT, Herzog CA, Ishani A, Israni AK, Ku E, Li S, Li S, Liu J, Obrador GT, O'Hare AM, Peng Y, Powe NR, Roetker NS, St Peter WL, Saeed F, Snyder J, Solid C, Weinhandl ED, Winkelmayer WC, Wetmore JB.

The core purpose of the ADR – to describe the epidemiology of kidney disease in the U.S. in support of public health, research, and policy initiatives to improve the care of individuals with acute kidney injury, chronic kidney disease, and end-stage renal disease.

Post-acute COVID-19 syndrome and kidney diseases: what do we know?

Copur, S., Berkkan, M., Basile, C., Tuttle, K., Kanbay, M.

COVID-19 presents various respiratory, cardiovascular, neuropsychiatric, musculoskeletal and kidney features during the acute phase; nevertheless, renal involvement in the post-infection period has recently been emphasized. The present review aims to evaluate the growing literature on kidney involvement in the SARS-CoV-2 infection along with clinical features reported both in the acute phase of the infection and in the post-acute COVID-19 period by assessing potential pathophysiological frameworks explaining such conditions.