Our research broadens the knowledge of kidney disease.

Weekly Standard Kt/Vurea and Clinical Outcomes in Home and In-Center Hemodialysis

Rivara MB, Ravel V, Streja E, Obi Y, Soohoo M, Cheung AK, Himmelfarb J, Kalantar-Zadeh K, Mehrotra R

Patients undergoing hemodialysis with a frequency other than thrice weekly are not included in current clinical performance metrics for dialysis adequacy. The weekly standard Kt/Vurea incorporates treatment frequency, but there are limited data on its association with clinical outcomes.

Metabolic Clusters and Outcomes in Older Adults: The Cardiovascular Health Study

Mukamal KJ, Siscovick DS, de Boer IH, Ix JH, Kizer JR, Djoussé L, Fitzpatrick AL, Tracy RP, Boyko EJ, Kahn SE, Arnold AM

Few studies have the requisite phenotypic information to define metabolic patterns that may inform our understanding of the pathophysiology and consequences of diabetes in older adults. We sought to characterize clusters of older adults on the basis of shared metabolic features.

Are we underestimating the quality of aviremic Hepatitis C positive kidneys? Time to reconsider

Sibulesky L, Kling CE, Blosser C, Johnson CK, Limaye AP, Bakthavatsalam R, Leca N, Perkins JD

Unintended Consequences in Use of Increased Risk Donor Kidneys in the New Kidney Allocation Era

Rahnemai-Azar AA, Perkins JD, Leca N, Blosser CD, Johnson CK, Morrison SD, Bakthavatsalam R, Limaye AP, Sibulesky L

The new kidney allocation system (KAS) intends to allocate the top 20% of kidneys to younger recipients with longer life expectancy. We hypothesized that the new KAS would lead to greater allocation of Public Health Service (PHS) increased-risk donor organs to younger recipients.

LMX1B-Associated Nephropathy With Type III Collagen Deposition in the Glomerular and Tubular Basement Membranes

Andeen NK, Schleit J, Blosser CD, Dorschner MO, Hisama FM, Smith KD

Variants in the LMX1B gene cause nail-patella syndrome, a rare autosomal dominant disorder characterized by dysplasia of nails, patella and elbow abnormalities, iliac “horns,” and glaucoma. We describe an adult man with nephrotic syndrome and no systemic manifestations of nail-patella syndrome at the time of his initial kidney biopsy.

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Nisha Bansal, Adam Szpiro, Kristi Reynolds, David H. Smith, David J. Magid, Jerry H. Gurwitz, Frederick Masoudi, Robert T. Greenlee, Grace H. Tabada, Sue Hee Sung, Ashveena Dighe, Alan S. Go

Chronic kidney disease (CKD) is common in adults with heart failure and is associated with an increased risk of sudden cardiac death. Randomized trials of participants without CKD have demonstrated that implantable cardioverter defibrillators (ICDs) decrease the risk of arrhythmic death in selected patients with reduced left ventricular ejection fraction (LVEF) heart failure. However, whether ICDs improve clinical outcomes in patients with CKD is not well elucidated.

Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-sulfate, A Major Circulating Vitamin D Metabolite in Humans

Timothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G Claw, Chunying Gao, Robert S Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G Schuetz, Ronald L Horst, Qingcheng Mao, Ian H de Boer, Timothy A Thornton and Kenneth E Thummel

Metabolism of 25-hydroxyvitamin D3 (25OHD3) plays a central role in regulating the biological effects of vitamin D in the body. Although cytochrome P450-dependent hydroxylation of 25OHD3 has been extensively investigated, limited information is available on the conjugation of 25OHD3.

Nephrology at a Crossroads

Increasing work demands, high rates of burnout, and declining interest in nephrology as a career—these are issues that touch the lives of nephrologists everywhere, threatening to reduce job satisfaction and impair delivery of high-quality care to patients with kidney diseases.

CJASN: What’s Behind and What’s Ahead

Rajnish Mehrotra, Michel Chonchol, Ian de Boer

The primary focus at CJASN has always been on publishing the highest-quality original research papers that move the field forward in a meaningful way. We are committed to maintain that as the primary focus of what we do. To promote rigorous and fair peer review, at least two editors evaluate every manuscript submitted to CJASN before deciding to send for external peer review. Three experts in the field evaluate most papers sent for external peer review, and the full editorial team evaluates favorably reviewed papers.

Patient-Centered Care in Renal Medicine: Five Strategies to Meet the Challenge

There is growing interest in patient-centered care, defined by the Institute of Medicine as “care that is respectful of and responsive to individual patient preferences, needs, and values.” Although generally accepted as uncontroversial, the notion of “centering” care on our patients is in fact quite revolutionary.