Our research broadens the knowledge of kidney disease.

End-of-Life Care for Patients With Advanced Kidney Disease in the US Veterans Affairs Health Care System, 2000-2011

Susan P.Y. Wong, Margaret K. Yu, Pamela K. Green, Chuan-Fen Liu, Paul L. Hebert, and Ann M. O’Hare

Although advances in medical science and technology have led to improvements in population health and longevity, the potential benefits of interventions intended to prolong life tend to diminish as patients approach the end of life.

Outcomes Associated With Left Ventricular Assist Devices Among Recipients With and Without End-stage Renal Disease

Bansal N, Hailpern SM, Katz RHall YN, Tamura MK, Kreuter W, O'Hare AM

Left ventricular assist devices (LVADs) are widely used as a bridge to heart transplant and as a destination therapy in advanced heart failure. The objective of this study was to determine the utilization of and outcomes associated with LVADs in nationally representative cohorts of patients with and without end-stage renal disease (ESRD).

Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity

Chang SY, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen D, Wang J, Rosenquist TA, Dickman KG, Neumann T, Grollman AP, Kelly EJ, Himmelfarb J, Eaton DL

Environmental exposures pose a significant threat to human health. However, it is often difficult to study toxicological mechanisms in human subjects due to ethical concerns.

The Effect of Extended Release Niacin on Markers of Mineral Metabolism in CKD

Malhotra R, Katz R, Hoofnagle A, Bostom A, Rifkin DE, Mcbride R, Probstfield J, Block G, Ix JH

Chronic kidney disease is common and strongly linked with risk of fractures, cardiovascular disease, and end stage renal disease. Kidney disease patients have higher serum phosphate levels, and higher phosphate may be causing the higher risk of these outcomes. We identified that the lipid drug niacin lowers serum phosphate through a unique mechanism.

Stuck in a Bind With Phosphate Binders

Kestenbaum B, Psaty BM

Associations and Presumed Mechanisms Are Inadequate for Predicting Drug Effects. Scores of observational studies demonstrate that lower high-density lipoprotein cholesterol (HDL-C) concentrations are associated with cardiovascular risk.

Commentary on Lessons from CKD-Related Genetic Association Studies-Moving Forward

Kestenbaum B, Seliger SL

KEYWORDS: Genetic Association Studies; Renal Insufficiency, Chronic

Impact of Obesity on Modality Longevity, Residual Kidney Function, Peritonitis, and Survival Among Incident Peritoneal Dialysis Patients

Obi Y, Streja E, Mehrotra RRivara MB, Rhee CM, Soohoo M, Gillen DL, Lau WL, Kovesdy CP, Kalantar-Zadeh K

The association between obesity and clinical outcomes among patients ESRD undergoing peritoneal dialysis (PD) remains unclear in the current era. This observational study analyzed 15,573 PD patients in the US and found that higher body mass index was associated with greater risk for peritonitis-related hospitalizations, rapid decline in residual kidney function, and more frequent transfers to in-center hemodialysis. There was no difference in risk for death among obese patients undergoing PD compared to those treated with hemodialysis.

Charting the transcriptional landscape of cells of renin lineage following podocyte depletion

McClelland AD, Lichtnekert J, Eng DG, Pippin JW, Gross KW, Gharib SA, Shankland SJ

Renin producing cells of the juxtaglomerulus, herein called cells of renin lineage (CoRL), have garnered recent interest for their propensity to act as a progenitor source for various kidney cell types including podocytes. Despite recent advances, the process of transdifferentiation of CoRL to podocytes is poorly understood.

Perioperative THR-184 and AKI after Cardiac Surgery

Jonathan Himmelfarb, Glenn M. Chertow, Peter A. McCullough, Thierry Mesana, Andrew D. Shaw, Thoralf M. Sundt, Craig Brown, David Cortville, François Dagenais, Benoit de Varennes, Manuel Fontes, Jerome Rossert, Jean-Claude Tardif

AKI after cardiac surgery is associated with mortality, prolonged hospital length of stay, use of dialysis, and subsequent CKD. We evaluated the effects of THR-184, a bone morphogenetic protein-7 agonist, in patients at high risk for AKI after cardiac surgery.

Acute Kidney Injury and Risk of Incident Heart Failure Among US Veterans

Bansal N, Matheny ME, Greevy RA Jr, Eden SK, Perkins AM, Parr SK, Fly J, Abdel-Kader K, Himmelfarb J, Hung AM, Speroff T, Ikizler TA, Siew ED

In this study of over 300,000 hospitalized U.S. Veterans, we found that acute kidney injury was associated with a 23% greater risk of developing incident heart failure within 2 years from hospital discharge.