Our research broadens the knowledge of kidney disease.

Lineage Tracing Aged Mouse Kidneys Shows Lower Number of Cells of Renin Lineage and Reduced Responsiveness to RAAS Inhibition

Hamatani H, Eng DG, Kaverina NV, Gross KW, Freedman B, Pippin JW, Shankland SJ.

Blocking the renin-angiotensin-aldosterone system (RAAS) remains a mainstay of therapy in hypertension and glomerular diseases. With the population aging, our understanding of renin producing cells in kidneys with advanced age is more critical than ever.

The United States Needs a National Policy on Dialysis for Undocumented Immigrants With ESRD

Lilia Cervantes, Monica Grafals, Rudolph A.Rodriguez

An estimated 6,500 undocumented immigrants with end-stage renal disease (ESRD) reside in the United States.1 The availability of standard outpatient (thrice-weekly) hemodialysis for undocumented immigrants with ESRD varies throughout the country. Although many states offer emergency-only hemodialysis (dialysis only after an emergency department evaluation), others offer standard hemodialysis.2 This considerable variation by state is due to the lack of a national policy.

Evaluation of Flexible Tacrolimus Drug Concentration Monitoring Approach in Patients Receiving Extended-Release Once-Daily Tacrolimus Tablets

Philosophe B, Leca N, West-Thielke PM, Horwedel T, Culkin-Gemmell C, Kistler K, Stevens DR

The majority of United States kidney transplant patients are treated with tacrolimus, a drug effective in preventing graft rejection, but with a narrow therapeutic range, necessitating close monitoring to avoid increased risks of transplant rejection or toxicity if the tacrolimus concentration is too low or too high, respectively. The trough drug concentration tests are time sensitive; patients treated on a twice-daily basis have blood draws exactly 12 hours after their previous dose. The schedule's rigidity causes problems for both patients and health care providers.

High fructose diet feeding accelerates diabetic nephropathy in Spontaneously Diabetic Torii (SDT) rats

Toyoda K, Suzuki Y, Muta K, Masuyama T, Kakimoto K, Kobayashi A, Shoda T, Sugai S

Diabetic nephropathy (DN) is one of the complications of diabetes and is now the most common cause of end-stage renal disease. Fructose is a simple carbohydrate that is present in fruits and honey and is used as a sweetener because of its sweet taste. Fructose has been reported to have the potential to progress diabetes and DN in humans even though fructose itself does not increase postprandial plasma glucose levels.

Relation of uric acid level to rapid kidney function decline and development of kidney disease: The Jackson Heart Study

Mwasongwe SE, Fülöp T2, Katz R, Musani SK, Sims M, Correa A, Flessner MF, Young BA

Whether elevated uric acid (UA) is an independent risk factor for chronic kidney disease (CKD) is not well established. The authors evaluated the relationship of UA with rapid kidney function decline (RKFD) and incident CKD among 3702 African Americans (AAs) in the Jackson Heart Study with serum UA levels measured at baseline exam (2000-2004).

Relationships Between Clinical Processes and Arteriovenous Fistula Cannulation and Maturation: A Multicenter Prospective Cohort Study

Allon M, Imrey PB, Cheung AK, Radeva M, Alpers CE, Beck GJ, Dember LM, Farber A, Greene T, Himmelfarb J, Huber TS, Kaufman JS, Kusek JW, Roy-Chaudhury P, Robbin ML, Vazquez MA, Feldman HI; Hemodialysis Fistula Maturation (HFM) Study Group

Half of surgically created arteriovenous fistulas (AVFs) require additional intervention to effectively support hemodialysis. Postoperative care and complications may affect clinical maturation.

Perioperative THR-184 and AKI after Cardiac Surgery

Himmelfarb J, Chertow GM, McCullough PA, Mesana T, Shaw AD, Sundt TM, Brown C, Cortville D, Dagenais F, de Varennes B, Fontes M, Rossert J, Tardif JC

Acute Kidney Injury after cardiac surgery is associated with mortality, prolonged hospital length of stay, use of dialysis, and subsequent Chronic Kidney Disease. We evaluated the effects of THR-184, a bone morphogenetic protein-7 agonist, in patients at high risk for AKI after cardiac surgery.

Weekly Standard Kt/Vurea and Clinical Outcomes in Home and In-Center Hemodialysis

Rivara MB, Ravel V, Streja E, Obi Y, Soohoo M, Cheung AK, Himmelfarb J, Kalantar-Zadeh K, Mehrotra R

Patients undergoing hemodialysis with a frequency other than thrice weekly are not included in current clinical performance metrics for dialysis adequacy. The weekly standard Kt/Vurea incorporates treatment frequency, but there are limited data on its association with clinical outcomes.

Metabolic Clusters and Outcomes in Older Adults: The Cardiovascular Health Study

Mukamal KJ, Siscovick DS, de Boer IH, Ix JH, Kizer JR, Djoussé L, Fitzpatrick AL, Tracy RP, Boyko EJ, Kahn SE, Arnold AM

Few studies have the requisite phenotypic information to define metabolic patterns that may inform our understanding of the pathophysiology and consequences of diabetes in older adults. We sought to characterize clusters of older adults on the basis of shared metabolic features.

Are we underestimating the quality of aviremic Hepatitis C positive kidneys? Time to reconsider

Sibulesky L, Kling CE, Blosser C, Johnson CK, Limaye AP, Bakthavatsalam R, Leca N, Perkins JD