Our research broadens the knowledge of kidney disease.

Circulating levels of soluble Fas (sCD95) are associated with risk for development of a nonresolving acute kidney injury subphenotype

Bhatraju PK, Robinson-Cohen C, Mikacenic C, Harju-Baker S, Dmyterko V, Slivinski NSJ, Liles WC, Himmelfarb J, Heckbert SR, Wurfel MM

Critically ill patients with acute kidney injury (AKI) can be divided into two subphenotypes, resolving or nonresolving, on the basis of the trajectory of serum creatinine. It is unknown if the biology underlying these two AKI recovery patterns is different.

Non-GFR Determinants of Low-Molecular-Weight Serum Protein Filtration Markers in the Elderly: AGES-Kidney and MESA-Kidney

Foster MC, Levey AS, Inker LA, Shafi T, Fan L, Gudnason V, Katz R, Mitchell GF, Okparavero A, Palsson R, Post WS, Shlipak MG

In this current study we showed that, in two elderly community based cohorts, cystatin C, β2-microglobulin (B2M), and beta-trace protein (BTP) were less affected by age and gender and unaffected by ethnicity than those of creatinine. These findings are important for the development of GFR estimating equations.

Development of a microphysiological model of human kidney proximal tubule function

Weber EJ, Chapron A, Chapron BD, Voellinger JL, Lidberg KA, Yeung CK, Wang Z, Yamaura Y, Hailey DW, Neumann T, Shen DD, Thummel KE, Muczynski KAHimmelfarb J, Kelly EJ

Coloduodenovesical Fistula After Simultaneous Pancreas-Kidney Transplant: Case Report and Review of the Literature

Rahnemai-Azar AA, Penna M, Morrison SD, Rayhill SC, Sibulesky L, Muczynski KA, Bakthavatsalam R

Complicated diverticulitis after transplantation occurs in as many as 3.5% of cases and carries a 25% mortality rate. Diagnosis of complicated diverticulitis in this population can be challenging because of abnormal presentations caused by immunosuppression. Only 4 cases of fistulization after kidney transplantation are described in the literature; none occurred after simultaneous pancreas-kidney transplant.

Making Sense of Prognostic Information About Maintenance Dialysis versus Conservative Care for Treatment of Advanced Kidney Disease

In an invited editorial, we discuss the findings of a recent meta-analysis of cohort studies comparing survival of patients who opted for maintenance dialysis vs. conservative medical management without dialysis for their end-stage renal disease. While some prior studies have reported longer survival among patients opting for dialysis, other studies have reported no difference in survival for older patients.

Embracing Complexity: How to Build an Evidence Base Capable of Supporting Patient-Centered Care

An editorial that reviews a study that used a Delphi process to identify research priorities for clinical studies in nephrology. What was radical about this study is that it included patients and caregivers along with nephrology providers in the outcome selection process. The editorial explains why it is so important to engage patients and their family and friends in formative aspects of study design. In this way we will be able to develop an evidence base capable of supporting care that prioritizes what matters most to individual patients.

Physical Activity Dose for Hemodialysis Patients: Where to Begin? Results from a Prospective Cohort Study

Matsuzawa R, Roshanravan B, Shimoda T, Mamorita N, Yoneki K, Harada M, Watanabe T, Yoshida A, Takeuchi Y, Matsunaga A

Sedentary lifestyle is associated with increased risk of death in dialysis patients. Although experts encourage regular physical activity among patients on hemodialysis, little is known about the minimal dose of physical activity and the association of the number of steps per day necessary to yield health benefits among patients treated with hemodialysis. This collaborative study is the first to determine how the number of steps taken on a daily basis predicts risk of death in patients treated with hemodialysis.

WT1 Is Necessary for the Proliferation and Migration of Cells of Renin Lineage Following Kidney Podocyte Depletion

Kaverina NV, Eng DG, Largent AD, Daehn I, Chang A, Gross KW, Pippin JW, Hohenstein P, Shankland SJ

Focal segmental glomerulosclerosis (FSGS) is a progressive form of kidney disease. The number of podocytes covering the glomerular capillaries decreases in (FSGS) and is widely accepted to be responsible for glomerular leak of plasma proteins.

Association of Serum Amyloid A with Kidney Outcomes and All-Cause Mortality in American Indians with Type 2 Diabetes

Saulnier PJ, Dieter BP, Tanamas SK, McPherson SM, Wheelock KM, Knowler WC, Looker HC, Meek RL, Nelson RG, Tuttle KR

Higher serum SAA concentrations were previously associated with increased risk of end-stage renal disease (ESRD) and death in persons with type 2 diabetes and advanced DKD. However, SAA may enhance tubular cell proliferation in acute kidney injury (AKI), suggesting that it is also capable of promoting kidney repair under some circumstances.

Chronic kidney disease and incident apparent treatment-resistant hypertension among blacks: Data from the Jackson Heart Study

Tanner RM, Shimbo D, Irvin MR, Spruill TM, Bromfield SG, Seals SR, Young BA, Muntner P