Our research broadens the knowledge of kidney disease.

Unintended Consequences in Use of Increased Risk Donor Kidneys in the New Kidney Allocation Era

Rahnemai-Azar AA, Perkins JD, Leca N, Blosser CD, Johnson CK, Morrison SD, Bakthavatsalam R, Limaye AP, Sibulesky L

The new kidney allocation system (KAS) intends to allocate the top 20% of kidneys to younger recipients with longer life expectancy. We hypothesized that the new KAS would lead to greater allocation of Public Health Service (PHS) increased-risk donor organs to younger recipients.

LMX1B-Associated Nephropathy With Type III Collagen Deposition in the Glomerular and Tubular Basement Membranes

Andeen NK, Schleit J, Blosser CD, Dorschner MO, Hisama FM, Smith KD

Variants in the LMX1B gene cause nail-patella syndrome, a rare autosomal dominant disorder characterized by dysplasia of nails, patella and elbow abnormalities, iliac “horns,” and glaucoma. We describe an adult man with nephrotic syndrome and no systemic manifestations of nail-patella syndrome at the time of his initial kidney biopsy.

lineag

Nisha Bansal, Adam Szpiro, Kristi Reynolds, David H. Smith, David J. Magid, Jerry H. Gurwitz, Frederick Masoudi, Robert T. Greenlee, Grace H. Tabada, Sue Hee Sung, Ashveena Dighe, Alan S. Go

Chronic kidney disease (CKD) is common in adults with heart failure and is associated with an increased risk of sudden cardiac death. Randomized trials of participants without CKD have demonstrated that implantable cardioverter defibrillators (ICDs) decrease the risk of arrhythmic death in selected patients with reduced left ventricular ejection fraction (LVEF) heart failure. However, whether ICDs improve clinical outcomes in patients with CKD is not well elucidated.

Polymorphic Human Sulfotransferase 2A1 Mediates the Formation of 25-Hydroxyvitamin D3-3-O-sulfate, A Major Circulating Vitamin D Metabolite in Humans

Timothy Wong, Zhican Wang, Brian D. Chapron, Mizuki Suzuki, Katrina G Claw, Chunying Gao, Robert S Foti, Bhagwat Prasad, Alenka Chapron, Justina Calamia, Amarjit Chaudhry, Erin G Schuetz, Ronald L Horst, Qingcheng Mao, Ian H de Boer, Timothy A Thornton and Kenneth E Thummel

Metabolism of 25-hydroxyvitamin D3 (25OHD3) plays a central role in regulating the biological effects of vitamin D in the body. Although cytochrome P450-dependent hydroxylation of 25OHD3 has been extensively investigated, limited information is available on the conjugation of 25OHD3.

Nephrology at a Crossroads

Increasing work demands, high rates of burnout, and declining interest in nephrology as a career—these are issues that touch the lives of nephrologists everywhere, threatening to reduce job satisfaction and impair delivery of high-quality care to patients with kidney diseases.

CJASN: What’s Behind and What’s Ahead

Rajnish Mehrotra, Michel Chonchol, Ian de Boer

The primary focus at CJASN has always been on publishing the highest-quality original research papers that move the field forward in a meaningful way. We are committed to maintain that as the primary focus of what we do. To promote rigorous and fair peer review, at least two editors evaluate every manuscript submitted to CJASN before deciding to send for external peer review. Three experts in the field evaluate most papers sent for external peer review, and the full editorial team evaluates favorably reviewed papers.

Patient-Centered Care in Renal Medicine: Five Strategies to Meet the Challenge

There is growing interest in patient-centered care, defined by the Institute of Medicine as “care that is respectful of and responsive to individual patient preferences, needs, and values.” Although generally accepted as uncontroversial, the notion of “centering” care on our patients is in fact quite revolutionary.

End-of-Life Care for Patients With Advanced Kidney Disease in the US Veterans Affairs Health Care System, 2000-2011

Susan P.Y. Wong, Margaret K. Yu, Pamela K. Green, Chuan-Fen Liu, Paul L. Hebert, and Ann M. O’Hare

Although advances in medical science and technology have led to improvements in population health and longevity, the potential benefits of interventions intended to prolong life tend to diminish as patients approach the end of life.

Outcomes Associated With Left Ventricular Assist Devices Among Recipients With and Without End-stage Renal Disease

Bansal N, Hailpern SM, Katz RHall YN, Tamura MK, Kreuter W, O'Hare AM

Left ventricular assist devices (LVADs) are widely used as a bridge to heart transplant and as a destination therapy in advanced heart failure. The objective of this study was to determine the utilization of and outcomes associated with LVADs in nationally representative cohorts of patients with and without end-stage renal disease (ESRD).

Human liver-kidney model elucidates the mechanisms of aristolochic acid nephrotoxicity

Chang SY, Weber EJ, Sidorenko VS, Chapron A, Yeung CK, Gao C, Mao Q, Shen D, Wang J, Rosenquist TA, Dickman KG, Neumann T, Grollman AP, Kelly EJ, Himmelfarb J, Eaton DL

Environmental exposures pose a significant threat to human health. However, it is often difficult to study toxicological mechanisms in human subjects due to ethical concerns.