Our faculty research broadens the knowledge of kidney disease.

Preformed Angiotensin II Type-1 Receptor Antibodies Are Associated With Rejection After Kidney Transplantation: A Single-Center, Cohort Study

Kim, D.,  Gimferrer, I.,  Warner, P.,  Nelson, K.,  Sibulesky, L.,  Bakthavatsalam, R.,  Leca, N.

Antibodies against angiotensin II type-1 receptors (AT1R) have been increasingly recognized in association with rejection and poor allograft outcomes. Our goal was to define the prevalence of preformed antibodies against AT1R and evaluate the association with renal allograft outcomes in a consecutive cohort of 150 transplant recipients.

Dietary Phosphorus and Ambulatory Blood Pressure in African Americans: The Jackson Heart Study

Olivo, R.E.,  Hale, S.L.,  Diamantidis, C.J.,  Bhavsar, N.A.,  Tyson, C.C.,  Tucker, K.L.,  Carithers, T.C.,  Kestenbaum, B.,  Muntner, P.,  Tanner, R.M.,  Booth, J.N., 3rd,  Mwasongwe, S.E.,  Pendergast, J.,  Boulware, L.E.,  Scialla, J.J.

 

Higher dietary phosphorus is associated with left ventricular hypertrophy and mortality, which are blood pressure (BP)-related outcomes. For this reason, we hypothesized that dietary phosphorus may be associated with adverse clinic and ambulatory BP patterns. Our study included 973 African American adults enrolled in the Jackson Heart Study (2000–2004) with 24-hour ambulatory BP monitoring (ABPM) data at baseline. We quantified dietary phosphorus from a validated Food Frequency Questionnaire.

Editorial: Diuretic use in incident ESKD. Are we out of the loop?

Wang K, Bansal N

Sibbel et al examined the association of loop diuretic continuation with clinical outcomes after maintenance hemodialysis initiation among >11,000 patients with incident ESKD. In this large, observational cohort study, the authors utilized US Renal Data System (USRDS) records to ascertain refill of loop diuretic prescriptions after hemodialysis initiation and within 30 days of exhaustion of prior diuretic supply.

Boronic Acid Copolymers for Direct Loading and Acid-Triggered Release of Bis-T-23 in Cultured Podocytes

Cheng, Y.,  Liu, G.W.,  Jain, R.,  Pippin, J.W.,  Shankland, S.J.,  Pun, S.H.

We report an acid-reversible linker for triggered release of Bis-T-23, an experimental small molecule drug for kidney disease treatment that restores podocyte morphology during disease. Bis-T-23 contains catechols, which form an acid-reversible, covalent boronate ester bond with boronic acids.

Obtaining Dialysis in VA and Non-VA Settings

Virginia Wang, Cynthia J. Coffman, Karen M. Stechuchak, Theodore S.Z. Berkowitz, Paul L. Hebert, David Edelman, Ann M. O’Hare, Susan T. Crowley, Hollis J. Weidenbacher, Matthew L. Maciejewski

Outcomes of veterans with ESRD may differ depending on where they receive dialysis and who finances this care, but little is known about variation in outcomes across different dialysis settings and financial arrangements. We examined survival among 27,241 Veterans Affairs (VA)–enrolled veterans who initiated chronic dialysis in 2008–2011.

Gene Expression Studies and Targeted Metabolomics Reveal Disturbed Serine, Methionine, and Tyrosine Metabolism in Early Hypertensive Nephrosclerosis

Øvrehus, M.A.,  Bruheim, P.,  Ju, W.,  Zelnick, L.R.,  Langlo, K.A.,  Sharma, K.,  de Boer, I.H.,  Hallan, S.I.

Hypertensive nephrosclerosis is among the leading causes of end-stage renal disease, but its pathophysiology is poorly understood. We wanted to explore early metabolic changes using gene expression and targeted metabolomics analysis. We analyzed gene expression in kidneys biopsied from 20 patients with nephrosclerosis and 31 healthy controls with an Affymetrix array. Thirty-one amino acids were measured by liquid chromatography coupled with mass spectrometry (LC-MS) in urine samples from 62 patients with clinical hypertensive nephrosclerosis and 33 age- and sex-matched healthy controls, and major findings were confirmed in an independent cohort of 45 cases and 15 controls.

The Association of Kidney Function and Albuminuria With the Risk and Outcomes of Syncope: A Population-Based Cohort Study

Massicotte-Azarniouch, D.,  Kuwornu, J.P.,  McCallum, M.K.,  Bansal, N.,  Lam, N.,  Molnar, A.O.,  Pun, P.,  Zimmerman, D.,  Garg, A.X.,  Sood, M.M.

The risks and subsequent outcomes of syncope among seniors with chronic kidney disease (CKD) are unclear. We conducted a population-based retrospective cohort study of 272,146 patients ≥ 66 years old, in Ontario, Canada, from April 1, 2006, to March 31, 2016. Using administrative health care databases, we examined the association of estimated glomerular filtration rate (eGFR) and urine albumin to creatinine ratio (ACR) with incident syncope and the association of incident syncope with the composite outcome of myocardial infarction, stroke, and death by levels of eGFR/ACR, using adjusted Cox proportional hazards models.

Comparative Assessment of Utilization and Hospital Outcomes of Veterans Receiving VA and Non-VA Outpatient Dialysis

Wang V, Coffman CJ, Stechuchak KM, Berkowitz TSZ, Hebert PL, Edelman D, O'Hare AM, Weidenbacher HJ, Maciejewski ML

Growing demand for VA dialysis exceeds its supply and travel distances prohibit many Veterans from receiving dialysis in a VA facility, leading to increased use of dialysis from non-VA providers. This study compared utilization and hospitalization outcomes among Veterans receiving chronic dialysis in VA and non-VA settings in 2008-2013

IgA-dominant glomerulonephritis with a membranoproliferative pattern of injury

Nicole K. Andeen, J. Ashley Jefferson, Shreeram Akilesh, Charles E . Alpers, Mei Lin Bissonnette, Laura S.Finn, John Higgins, Donald C.Houghton, Neeraja Kambham, Alex Magil, Behzad Najafian MD, Roberto F. Nicosia, Megan L.Troxell, Kelly D.Smith

Immunoglobulin A (IgA)-dominant membranoproliferative glomerulonephritis (MPGN) is a descriptive term for renal biopsies in which differential diagnoses of unusual IgA nephropathy (IgAN), infection-related GN, or other etiologies are considered. We sought to understand clinical and pathologic features of this finding. Native kidney biopsies with IgA-dominant immune deposits and diffuse MPGN features without significant exudative features or subepithelial deposits were retrospectively reviewed.

Soluble ST2 and Galectin-3 and Progression of CKD

Mariam L. Alam, Ronit Katz, Keith A. Bellovich, Zeenat Y. Bhat, Frank C. Brosius, Ian H.de Boer, Crystal A.Gadegbeku, Debbie S. Gipson, Jennifer J. Hawkins, Jonathan Himmelfarb, Bryan R. Kestenbaum, Matthias Kretzler, Cassianne Robinson-Cohen, Susan P. Steigerwalt, CourtneyTuegel, Nisha Bansal

Cardiac biomarkers soluble ST2 (sST2) and galectin-3 may reflect cardiac inflammation and fibrosis. It is plausible that these mechanisms may also contribute to the progression of kidney disease. We examined associations of sST2 and galectin-3 with kidney function decline in participants with chronic kidney disease (CKD).