Our research broadens the knowledge of kidney disease.

Read up-to-date Nephrology faculty research on Pubmed with the link below

University of Washington Nephrology Faculty Research on Pubmed

We are committed to conducting path-breaking research in order to improve the lives of people with kidney diseases. Our faculty consistently publish new research in nationally recognized journals.


A selection of recent papers:

 

Recurrence of glomerulonephritis after kidney transplant

Alawieh R, Boonpheng B, Blosser CD

Full text sources available.

A Heartwarming Role of the Proximal Tubules

Kidney function plays a central role in the evaluation and management of heart failure. Accurate and timely monitoring of kidney function is necessary for....

Acute liver failure secondary to acute antibody mediated rejection after compatible liver transplant: A case report

Todd J Robinson, James B Hendele, Idoia Gimferrer, Nicolae Leca, Scott W Biggins, Jorge D Reyes, Lena Sibulesky

The liver has traditionally been regarded as resistant to antibody-mediated rejection (AMR). AMR in liver transplants is a field in its infancy compared to kidney and lung transplants. In our case we present a patient with alpha-1-antitrypsin disease who underwent ABO compatible liver transplant complicated by acute liver failure (ALF) with evidence of antibody mediated rejection on allograft biopsy and elevated serum donor-specific antibodies (DSA). This case highlights the need for further investigations and heightened awareness for timely diagnosis.

APOL1 genotype-associated morphologic changes among patients with focal segmental glomerulosclerosis

Zee J, McNulty MT, Hodgin JB, Zhdanova O, Hingorani S, Jefferson JA, Gibson KL, Trachtman H, Fornoni A, Dell KM, Reich HN, Bagnasco S, Greenbaum LA, Lafayette RA, Gipson DS, Brown E, Kretzler M, Appel G, Sambandam KK, Tuttle KR, Chen D, Atkinson MA, Hogan MC, Kaskel FJ, Meyers KE, O'Toole J, Srivastava T, Sethna CB, Hladunewich MA, Lin JJ, Nast CC, Derebail VK, Patel J, Vento S, Holzman LB, Athavale AM, Adler SG, Lemley KV, Lieske JC, Hogan JJ, Gadegbeku CA, Fervenza FC, Wang CS, Matar RB, Singer P, Kopp JB, Barisoni L, Sampson MG.

Background: The G1 and G2 alleles of apolipoprotein L1 (APOL1) are common in the Black population and associated with increased risk of focal segmental glomerulosclerosis (FSGS). The molecular mechanisms linking APOL1 risk variants with FSGS are not clearly understood, and APOL1’s natural absence in laboratory animals makes studying its pathobiology challenging. Methods: In a cohort of 90 Black patients with either FSGS or minimal change disease (MCD) enrolled in the Nephrotic Syndrome Study Network (58% pediatric onset), we used kidney biopsy traits as an intermediate outcome to help illuminate tissue-based consequences of APOL1 risk variants and expression. We tested associations between APOL1 risk alleles or glomerular APOL1 mRNA expression and 83 light- or electron-microscopy traits measuring structural and cellular kidney changes.

Mission and one-year outcomes of a cardio-renal subspecialty consultation service

The population of patients with or at risk for concomitant kidney and heart disease, often termed “cardiorenal” disease, is large and continues to grow. Numerous studies have documented excess mortality risk as well as significant morbidity in this patient subpopulation. The interaction of kidney and heart disease leads to unique pathophysiology, disease manifestations, and treatment, necessitating specialized care that may not be addressed adequately by either cardiology or nephrology alone. Further, recent advances in kidney and cardiovascular technologies and devices have made the care of these patients increasingly complex. Together, there is a pressing, unmet need to develop specialized models of care for patients with combined kidney and heart disease. In response, the University of Washington (UW) launched the Kidney-Heart Service in August 2020.

Early Trajectory of Estimated Glomerular Filtration Rate and Long-term Advanced Kidney and Cardiovascular Complications in Type 1 Diabetes

Perkins BA, Bebu I, Gao X, Karger AB, Hirsch IB, Karanchi H, Molitch ME, Zinman B, Lachin JM, de Boer IH

OBJECTIVE: Rapid loss of estimated glomerular filtration rate (eGFR) within its normal range has been proposed as a strong predictor of future kidney disease. We investigated this association of eGFR slope early in the course of type 1 diabetes with long-term incidence of kidney and cardiovascular complications. RESEARCH DESIGN AND METHODS: The annual percentage change in eGFR (slope) was calculated during the Diabetes Control and Complications Trial (DCCT) for each of 1,441 participants over a mean of 6.5 years and dichotomized by the presence or absence of early rapid eGFR loss (slope ≤−3% per year) as the exposure of interest. Outcomes were incident reduced eGFR (eGFR <60 mL/min/1.73 m2), composite cardiovascular events, or major adverse cardiovascular events (MACE) during the subsequent 24 years post-DCCT closeout follow-up.

Older Patients with Advanced Chronic Kidney Disease and Their Perspectives on Prognostic Information: a Qualitative Study

Thorsteinsdottir B, Espinoza Suarez NR, Curtis S, Beck AT, Hargraves I, Shaw K, Wong SPY, Hickson LJ, Boehmer KR, Amberg B, Dahlen E, Wirtz C, Albright RC, Kumbamu A, Tilburt JC, Sutton EJ.

Background: Prognostic information is key to shared decision-making, particularly in life-limiting illnesses like advanced chronic kidney disease (CKD). Objective: To understand the prognostic information preferences expressed by older patients with CKD. Design and Participants: Qualitative study of 28 consecutively enrolled patients over 65 years of age with non-dialysis dependent CKD stages 3b-5, receiving care in a multi-disciplinary CKD clinic.

Functionality of Scarce Healthcare Resource Triage Teams During the COVID-19 Pandemic: A Multi-Institutional Simulation Study

Butler, Catherine, Webster, Laura, Sakata, Vicki, Tonelli, Mark, Diekema, Douglas, Gray, Megan

Plans for allocating scarce healthcare resources during the COVID-19 pandemic commonly involve the activation of institutional triage teams. These teams would be responsible for selecting patients who are most likely to survive to be prioritized to receive scarce resources. However, there is little empirical support for this approach.

A Diverse Spectrum of Immune Complex- and Complement-Mediated Kidney Diseases Is Associated With Mantle Cell Lymphoma

Nicole K. Andeen, Shahad Abdulameer, Vivek Charu, Jonathan E. Zuckerman, Megan Troxell, Neeraja Kambham, Charles E. Alpers, Behzad Najafian, Roberto F. Nicosia, Kelly D. Smith, Vanderlene L. Kung, Rupali S. Avasare, Anusha Vallurupalli, J. Ashley Jefferson, Douglas Hecox, Leah Swetnam, Michifumi Yamashita, Mercury Lin, Mei Lin Bissonnette, Shreeram Akilesh, Jean Hou

Introduction: There are limited reports on kidney biopsy findings in patients with mantle cell lymphoma (MCL). Methods: We initiated a multi-institutional, retrospective review of kidney biopsy findings in patients with active and treated MCL. Results: A total of 30 patients with MCL and kidney biopsies were identified, with a median age of 67 (range 48–87) years, 73% of whom were men. A total of 20 patients had active MCL at the time of biopsy, of whom 14 (70%) presented with acute kidney injury (AKI), proteinuria, and/or hematuria, and biopsy findings potentially attributable to lymphoma. Of the 14, 11 had...

Angiopoietins as Prognostic Markers for Future Kidney Disease and Heart Failure Events After Acute Kidney Injury

Mansour S, Bhatraju P, Coca S, Obeid W, Wilson F, Stanaway I, Jia Y, Thiessen Philbrook H, Go A, Ikizler TA, Siew E, Chinchilli V, Hsu CY, Garg A, Reeves WB, Liu K, Kimmel P, Kaufman J, Wurfel M, Himmelfarb J, Parikh S, Parikh C.

Background: The mechanisms underlying long-term sequelae following acute kidney injury (AKI) remain unclear. Vessel instability, an early response to endothelial injury, may reflect a shared mechanism and early trigger for chronic kidney disease (CKD) and heart failure. Methods: To investigate whether plasma angiopoietins, markers of vessel homeostasis, are associated with CKD progression and heart failure admissions after hospitalization in patients with and without AKI, we conducted a prospective cohort study to analyze the balance between angiopoietin-1 (Angpt-1), which maintains vessel stability, and angiopoietin-2 (Angpt-2), which increases vessel destabilization.