Our faculty research broadens the knowledge of kidney disease.

Advanced dialysis fellowship

Munshi R, Winrow RM, Wu JS, Treit K, Bieber SD

End‐stage renal disease (ESRD) requiring dialysis or transplantation once thought to be an orphan disease now affects over 400,000 patients in the United States.Currently, renal transplantation offers the best option for renal replacement therapy. However, majority of patients with ESRD are treated by dialysis. Significant advancements have been made in dialysis technology since chronic dialysis became a viable option in 1960.

Recurrent Polyuria

Arora N, Durvasula R

To recognize fellowship programs’ educational mission, AJKD is using its popular Quiz feature to highlight Nephrology Fellowship programs when an author is a Nephrology Fellow. To participate, Fellowship Program Directors mentor fellows in submitting prospective Quizzes; those that are selected for publication include a brief description of the fellowship program from the Director. For “Recurrent Polyuria,” the first author is Nayan Arora, a Nephrology Fellow at the University of Washington.

Prevalence of Hypertension and Cardiovascular Risk According to Blood Pressure Thresholds Used for Diagnosis

Lamprea-Montealegre JA, Zelnick LR, Hall YN, Bansal N, de Boer IH

We sought to estimate the prevalence of hypertension and characteristics of hypertensive adults in the United States according to blood pressure (BP) thresholds used for diagnosis and estimate their associated cardiovascular disease risk.

Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip

Sakolish C, Weber EJ, Kelly EJ, Himmelfarb J, Mouneimne R, Grimm FA, House JS, Wade T, Han A, Chiu WA, Rusyn I

Tissue chips are promising new technology, they have the potential to serve as a valuable tool in biomedical research, as well as pharmaceutical development with regards to testing for efficacy and safety. The principal goals of this study were to validate a previously established proximal tubule tissue chip model in an independent laboratory and to extend its utility to testing of nephrotoxic compounds.

Can we mitigate the effects of simultaneous liver-kidney transplantation through increased utilization of HCV-positive donors?

Sibulesky L, Perkins JD, Landis CS, Johnson CK.

The MELD era has seen a significant rise in the numbers of simultaneous liver‐kidney transplantations (SLK). Prior to August 2017 there had not been any specific national policy addressing the allocation of the deceased‐donor kidneys to patients with liver failure who were on dialysis or with renal failure. A new SLK policy was recently implemented, establishing standardized national guidelines for the allocation of kidneys to SLK recipients

Simultaneous liver and kidney transplantation: How to expand the kidney donor pool?

Walter K, Johnson CK, Sibulesky L

Simultaneous dual-kidney liver transplantation (DLKT) in the United States. The first thing that strikes us is the very rarity of the procedure.

Utilization of Standard Criteria Donor and Expanded Criteria Donor Kidneys After Kidney Allocation System Implementation

Kling CE, Perkins JD, Johnson CK, Blosser CD, Leca N, Sibulesky L

Implementation of the Kidney Allocation System (KAS) changed how kidneys are allocated and the information on which organ utilization decisions are based. We aimed to evaluate how KAS implementation changed kidney utilization and recipient outcomes.

Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium

Inker LA, Grams ME, Levey AS, Coresh J, Cirillo M, Collins JF, Gansevoort RT, Gutierrez OM, Hamano T, Heine GH, Ishikawa S, Jee SH, Kronenberg F, Landray MJ, Miura K, Nadkarni GN, Peralta CA, Rothenbacher D, Schaeffner E, Sedaghat S, Shlipak MG, Zhang L, van Zuilen AD, Hallan SI, Kovesdy CP, Woodward M, Levin A; CKD Prognosis Consortium (Katz R)

Chronic kidney disease (CKD) is complicated by abnormalities that reflect disruption in filtration, tubular, and endocrine functions of the kidney. Our aim was to explore the relationship of specific laboratory result abnormalities and hypertension with the estimated glomerular filtration rate (eGFR) and albuminuria CKD staging framework.

Utilization of Standard Criteria Donor and Expanded Criteria Donor Kidneys After Kidney Allocation System Implementation

Kling CE, Perkins JD, Johnson CK, Blosser CD, Leca N, Sibulesky L

Implementation of the Kidney Allocation System (KAS) changed how kidneys are allocated and the information on which organ utilization decisions are based. We aimed to evaluate how KAS implementation changed kidney utilization and recipient outcomes.

Urine Complement Proteins and the Risk of Kidney Disease Progression and Mortality in Type 2 Diabetes

Vaisar T, Durbin-Johnson B, Whitlock K, Babenko I, Mehrotra R, Rocke DM, Afkarian M

We examined the association of urine complement proteins with progression to end-stage renal disease (ESRD) or death in people with type 2 diabetes and proteinuric diabetic kidney disease (DKD).